| There
is a lot of concern about the two studies released recently
regarding post menopausal hormone therapy and a new understanding of
the risks and benefits. There are two separate groups: One study looked at
combination hormone therapy with premarin and medroxyprovera--Prempro. In
this study it was found that there was a definite increase in breast
cancer. This was thought to be related to the Provera (medroxyprogesterone) component.
It has not been proven or disproved whether other progestins will have
similar increases but it anticipated that they will not. One of my
consultants has said that other progestins like those in Activella, FemHrt,
and OrthoPrefest are not likely to increase the risk of breast cancer.
Estrogen may turn out to be either not a risk factor or even somewhat
protective. Tamoxifen may even prevent breast cancer because it acts like
estrogen. The magnitude of the results was on the order of an
increase from an expected 12 cases of breast cancer in 10,000 people to 20
cases.
The second study looked at women who had had
hysterectomy and were on only estrogen. They found a slight increase in
ovarian cancer in the women taking estrogen. The percentages were
significant statisticaly but the numbers were really small. As I understand the article
they expected 5 cases of cancer in the study group and found 8, again this
is per 10,000 people. This is a
significant increase but in the thousands of people studied it is still a
very small risk.
The benefits of hormone therapy are also questioned in
these studies. There is certainly an improvement in bone density, but this
can be achieved with other medicines just as well. The improvement in
heart disease was not proven but some authorities have questioned the
presentation of the data. . The case for preventing colon cancer and
Alzheimer's disease is not well established and there are conflicting
studies. Estrogen therapy does prevent
night sweats and hot flashes better than any other therapy. Some people
will have improvement with soy, black cohosh, vitex, vitamin E and other
things but the improvement is not nearly as good as with estrogen.
Another more recent study suggests that people who have
begun estrogen around menopause and continue will have a lower risk of
heart disease and stroke but people who start estrogen after a number of
years will have an increase.
What to do? Don't panic. It won't matter
whether you stop the hormones or continue for another couple of months.
The reports are still new and the implications and significance is still
uncertain. We don't know if they will publish a retraction or a new
study in another
month. Who knows? Make an appointment with your doctor and discuss what hormone therapy has
to offer you. Everyone's case and everyone's needs are different. We can
work out a program that will help you.
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